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The influence of flow additives of powder behavior

9 Mar 2021  |
Many powders have poor basic flow properties: They block in hoppers and die feed frames, exhibit inconsistent or pulsatile discharge rates, adhere to surfaces of equipment, or don’t mix readily with other materials.

In such cases, it is possible to reduce particle-particle friction and change the powder’s bulk resistance to movement by the addition of a lubricant powder. Magnesium Stearate is used extensively as a lubricant in the manufacture of pharmaceutical oral solid dosage forms. It is commonly added to formulations in low concentrations (typically < 1% w/w) immediately prior to tableting.

Over a range of processes, however, the relationship between flow additive and the substrate is less well-understood. Due to the differing demands placed on powders by different processes, the relative influence of a given additive on a given substrate may not be consistent under all circumstances.

Freeman Technology’s study details experimental research on a range of typical excipients to demonstrate how powder rheology can be used to quantify the impact of flow additives. A particular focus is on how to optimize processability and cost-efficiency by identifying a suitable grade of lubricant and incorporating it at an appropriate concentration.

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Freeman Technology specialises in systems for measuring the flow properties of powders and has over a decade of experience in powder flow and powder characterisation. The company invests significantly in R&D and applications development, and...

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